- Daniel Radcliffe as Harry Potter, who makes a decision to find the remaining Horcruxes, not returning for his seventh year at Hogwarts.
- Rupert Grint as Ron Weasley, one of Harry's two best friends.
- Emma Watson as Hermione Granger, one of Harry's two best friends.
- Robbie Coltrane as Rubeus Hagrid, the Hogwarts gamekeeper and Care of Magical Creatures teacher, Harry's first friend from the magical world.
- David Thewlis as Remus Lupin, former Defence Against the Dark Arts teacher. Lupin is a werewolf and a member of the Order of the Phoenix.
- Matthew Lewis as Neville Longbottom, a slightly nerdy friend of Harry, Ron, Hermione, Ginny and Luna.
- Evanna Lynch as Luna Lovegood, one of Harry's friends and member of Dumbledore's Army
- Helena Bonham Carter as Bellatrix Lestrange, one of Voldemort's principal Death Eaters, older sister of Narcissa Malfoy, aunt to Draco, and cousin of Sirius Black, whom she murdered in Harry Potter and the Order of the Phoenix.
- Jason Isaacs as Lucius Malfoy. Isaacs considered not returning for the film, before the book was released, as he was worried Malfoy would have very little screentime due to the character's imprisonment in the previous story.
- Helen McCrory as Narcissa Malfoy, Draco's mother and younger sister of Bellatrix.
- Timothy Spall as Peter Pettigrew, former member of Harry's father James's group of friends, he betrayed Harry's parents to Voldemort. Now one of Voldemort's principal Death Eaters.
Lots of interesting characters in Harry Potter and the Deathly Hallows!